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Heery JM, Kozak M, Stafforini DM, Jones DA, Zimmerman GA, McIntyre TM, Prescott SM

N Engl J Med 387(3):205216 Jastreboff AM, le Roux CW, Stefanski A, Aronne LJ, Halpern B, Wharton S, Wilding JPH, Perreault L, Zhang S, Battula R, Bunck MC, Ahmad NN, Jouravskaya I (2025) SURMOUNT-1 investigators

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The mechanistic core of the finding was that Dihexa activated the PI3K/AKT signaling pathway in the brains of the APP/PS1 mice, and that the PI3K inhibitor wortmannin reversed Dihexas anti-inflammatory and anti-apoptotic effects [5]

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