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A 2021 systematic review of the potential adverse effects of microneedling, covering 51 studies and 1,029 patients across roller, stamp, pen, and radiofrequency devices, concluded that microneedling, regardless of the device used, is a relatively safe procedure with minimal adverse effects, the expected ones being redness, pain, mild swelling, and temporary skin irritation

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Liver Int 39 , 115126 (2019)

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Biochem Pharmacol 1989, 38: 347-352