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The American Society for Anesthesiology updated their pre-operative fasting guidelines in 2023 and recommended that GLP-1 receptor agonists should be held for 1 week, despite lacking data
however, work is needed to understand this process and how dietary intake, body weight, genetic predisposition for PDAC, and hyperglycemia promote or inhibit this progression
Specifically, delayed gastric emptying and the potential presence of retained gastric contents despite adherence to standard fasting guidelines have raised questions regarding the risk of regurgitation and pulmonary aspiration during general anesthesia and deep sedation
When specific nutrients reach the small intestine, they interact with receptors on L-cells, triggering GLP-1 release
Sprays usually reach peak plasma levels more quickly than injections
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