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Cancer Res 54 : 22182222 Resnicoff M, Tjuvajev J, Rotman HL, Abraham D, Curtis M, Aiken R, Baserga R (1996) Regression of C6 rat brain tumors by cells expressing an antisense insulin-like growth factor I receptor RNA

MMNST exhibited downregulation of genes involved in Schwann cell function, e.g., PMP22, PMP2, and MPZ, while genes related to melanin synthesis were upregulated in MMNST compared to schwannoma

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Instead, it exemplifies how endogenous peptides exhibiting multi-receptor activity were historically disadvantaged by a development paradigm that prioritized single-target selectivity over physiological relevance

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