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In contrast to the stimulation of ghrelin observed in mice, intragastric administration of another bitter tastant, quinine-hydrochloride (HCl quinine, 10 umol/kg), reduced fasting plasma ghrelin and motilin levels in healthy women (63), associated with increased activity in hedonic and homeostatic brain regions on functional magnetic resonance imaging, and suppressed antral motility and energy intake (57)

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Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation