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You may stay on a lower dose for longer if a higher dose causes side effects, or if you are happy with your weight loss without moving up

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It will: Validate the efficacy signals at larger scale, and at higher resolution Identify predictive markers of safety and tolerability Assess drug-specific differences in different applications Evaluate discontinuation and rebound risk Enable head-to-head drug comparisons as data matures This moves the program from proof-of-concept to clinically actionable stratification