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Treatment Options for Vitamin B12 Deficiency Treatment of vitamin B12 deficiency in the UK is guided by the underlying cause, severity of deficiency, and presence of neurological symptoms, following recommendations from NICE and the British National Formulary (BNF)

doi: 10.1136/annrheumdis-2015-209064 306 KleinKKabalaPAGrabiecAMGayREKollingCLinLLet al

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Supplements and Down syndrome There are mixed data regarding whether people with Down syndrome require the active forms (versus inactive forms) of vitamin B12 and folate when taking a supplement