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Tesamorelin (trade name Egrifta, Theratechnologies) received FDA approval in November 2010 for the reduction of excess abdominal fat (lipodystrophy) in HIV patients undergoing antiretroviral therapy

Wegovy, also given once weekly, was first approved in 2021 for weight loss in adults with obesity

This may allow the peptide to remain active for longer and to produce a more sustained receptor signal, possibly

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Klebsiella pneumoniae ST258 negatively regulates the oxidative burst in human neutrophils