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However, as relatively few reports have investigated the side effects of blood sugar changes, further research is necessary to confirm these effects

(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)

For long-term storage, freezing at -20C helps keep it pure and stable

This is because glutathione helps neutralize the free radicals produced during physical exertion

Nature Immunology , 25 (10), 18451857