These receptors promote downstream pathways that are important for appetite regulation, insulin sensitivity, and metabolism, among other benefits, and so lead to improvements in weight and metabolic health. Ali adds that the stimulation slows stomach emptying, increasing the chance a patient is satiated longer (and therefore eats less)
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GLP-1+GIP dual-agonists - such as tirzepatide - add a second mechanism: mimicking GIP (glucose-dependent insulinotropic polypeptide), which targets additional hormonal pathways involved in appetite and blood sugar regulation
Diabetes-related causes: Type 2 diabetes itself is a common cause of fatigue