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On the other hand, it is worrisome that up to 42% of patients who were treated with GLP-2 analog in induction phase discontinued the study (Buchman et al

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Together, these effects lead to the immunogenic cell death of tumor cells and alleviate PD-L1-mediated immune evasion, which further remodels the immunosuppressive TME and triggers a robust immune response, effectively inhibiting bilateral tumor progression and metastasis [76]