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Extended heat exposure can cause: Color darkening or brownish shifts Cloudiness from peptide aggregation Visible particle formation Loss of potency even without visible changes If your medication was shipped without adequate cold chain protection, or if it sat in a hot mailbox or delivery vehicle for hours, inspect it carefully before use

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Most patients report a mild cooling sensation as the fluid infuses, and many use the time to rest or to sit with numbing cream if a treatment appointment follows the IV