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Earlier laboratory research suggests it may also help restore the activity of aldehyde dehydrogenase 2, an enzyme that helps protect heart cells from damage caused by stress and toxic byproducts of metabolism

This observation leads to the question of whether supraphysiological stimulation (as occurs with GLP-1RA use) could accelerate the progression of PanIN lesions into PDAC

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doi: 10.1073/pnas.0804812105 86 AtarashiKTanoueTShimaTImaokaAKuwaharaTMomoseYet al