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Along with the plasma proteome and urine metabolome, the immune cell dynamics of the single cells isolated from the patients blood between the first and second trimesters can also predict the onset of PE and correlated with the aforementioned markers in plasma and urine

Importantly, the GAP activity of TBC1D9B towards ARL8B was comparable to its ability to stimulate GTP hydrolysis by its known substrate RAB11A (Supplementary Fig

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