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Interestingly, direct injections of Ex-4 into the gustatory cortex of mice maintained on a high-fat diet reduced intake only when the fat density of the test diet differed from that of the maintenance diet, regardless of whether the shift was from high- to low-fat or low- to high-fat relative to the maintenance diet

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Dosage Standard adult dose: Loading dose: 300600 mg orally (for ACS / PCI) Maintenance: 75 mg orally once daily Pediatric use: Not commonly indicated