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In prokaryotes, glutathione maintains the proper oxidation states of protein thiols and protects cells from damage under abnormal conditions such as low pH, chlorine compounds, oxidative and osmotic stresses 8

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In approximately 80% of cases, the upper extremities are also involved, with the tissue accumulation terminating abruptly at the wrists to create a cuffing effect (Al-Ghadban et al., 2019a)