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The occurrence of cerebrovascular diseases such as cerebral ischemia is often accompanied by BBB disruption, which facilitates the entry of bone marrow cells and bone-derived cytokines into the CNS, where they can have a variety of consequences
Neurosteroids, such as PregS have been implicated in disturbances of sleep and cognitive dysfunction in AD rodent models (247, 256)
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High dose thiamine supplementation has been shown to improve hyperglycemia symptoms in pre-diabetic individuals
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