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Habit-forming: No habit-forming tendencies were reported for this medicine

Glucose metabolism disorders are mainly driven by insulin resistance and accumulation of advanced glycosylation end products (AGEs), which lead to the occurrence of hyperglycemia and renal fibrosis by downregulating glucose transporter type 4 (GLUT4) expression and upregulating the receptor for advanced glycation end-products (RAGE)/NF-B pathway

Critical knowledge gaps persist in both unresolved basic enzymology and the comprehensive understanding of their multi-level regulation

Endocrine and thyroid function of polyphenols are also susceptible to dosage issues

Chemoecology 20(1):1118