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Large-scale human studies evaluating long-term exposure, systemic absorption, and potential adverse effects remain limited

The average (mean) BMI was 38 at the start of the trial

Roches NVIDIA AI Factory Expansion 2.1 Deployment of GPUs and Architecture In March 2026, Roche formally announced its global AI infrastructure expansion in partnership with NVIDIA ( [42] )

The PIONEER clinical trial program, a global phase III program enrolling over 9,500 participants across 12 studies, established the safety and tolerability of oral semaglutide across a range of doses and patient populations