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In this narrative literature review, we explore the pharmacological properties of tirzepatide and critically summarize and comment on the results of the clinical studies conducted thus far, as well as discuss the potential implications for the treatment of obesity, T2DM, and associated cardiometabolic complications

These motions are consistent with the loss of key interactions mediated by Tyr 37 of amylin peptides and the poor resolution of the RAMP3 ECD in the 3D EM map reconstructions

What about human studies