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Merck is advancing its metabolic disease portfolio by researching GLP-1 analogs and combination therapies that offer improved weight loss and glycemic control

doi:10.1002/em.20452

DNA methylation signatures may be applied for quantification of disease activity and patient stratification towards individualized treatment

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Multiple preclinical studies have demonstrated that co-targeting glycolysis and mitochondrial metabolism, or modulating key metabolic regulators such as AMPK, can significantly enhance the sensitivity of CRC cells to chemotherapy and targeted agents