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Markers of apoptosis, including elevated Bax and caspase-3 along with reduced Bcl-2, were significantly dysregulated in the STZ-induced diabetic group in this study, indicating enhanced pro-apoptotic signaling and mitochondrial dysfunction 55,56

The FDA-approved indications focus on glycemic control in type 2 diabetes and chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity, with some products (Wegovy, Saxenda) also approved for certain adolescents

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A Dionex UltiMate 3000 506 LC System (Thermo Scientific) and a Q Exactive Orbitrap mass spectrometer (Thermo Scientific) operated in negative mode was used for targeted measurement

Prothrombin time (PT), activated partial thromboplastin time (APTT), the international normalized ratio (INR), and fibrinogen (FIB) were measured by magnetic bead coagulation method