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P2Y 2 receptor agonists, denufosol (OLIYNYK et al., 2010), were promising for their ability to activate alternative chloride secretion pathways, but both of these agonists have not been pursued further due to not meeting primary study goals of improving FEV 1 (Ratjen et al., 2012) and having a narrow effective concentration range, respectively (OLIYNYK et al., 2010)

Originally developed as an anti-obesity drug candidate in the late 1990s, it has since found research applications in both metabolic studies and cartilage repair investigations

Acknowledgments The authors acknowledge the Vollum Institute for providing support for the initial meeting of authors for a roundtable conference on controversies in MOR regulation that initiated the development of the review

Keep your hCG kit in the refrigerator and out of the reach of children