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This technique measures total vitamin B12 using a ruthenium-label recombinant porcine intrinsic factor as the reporter probe

All doses markedly suppressed food intake compared to vehicle controls, with the 30 and 300 nmol/kg doses producing the strongest anorectic effects, reducing 24-hour food intake by 51% and 57%, respectively

Any combined use is based on theoretical pharmacology and individual drug studies rather than robust clinical evidence, making it an investigational approach

Carlo Fabian (University of Applied Sciences and Arts, Northwestern Switzerland), Federico Savini (University of Amsterdam), Prof

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