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To view a copy of this licence, visit About this article Cite this article Fang, C., Feng, D., Gaines, M

A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication

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Dosage form optimization: Controlled-release formulations enabling once-weekly oral administration Indication expansion: NASH, Alzheimers disease, cardiovascular protection Conclusion: A game-changing Molecule Design Orforglipron represents a triumph in small molecule drug designit demonstrates that clever chemical structure design can break through the dominance of biologics