3.3 Superoxide Dismutase Response Non-exposed groups 1 to 3 showed relatively similar response for the activity of SOD in testicular cells
Unlike genetic resistance, these phenotypes enable fungal cells to survive high concentrations of antifungals without a measurable increase in minimum inhibitory concentration (MIC), contributing to chronic and relapsing infections ( Cryptococcus can enter a quiescent state that confers high tolerance to AmB (Ke et al., 2024)
Lower doses of the nanoparticle-based formulation showed enhanced efficacy, with in vivo toxicity studies confirming its safety at the tested levels (466)
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