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In the assessment of the effect of salicin on arthritis in vivo, treatment with 15 mg/kg salicin resulted in a reduction in clinical arthritis scores, accompanied by a significant improvement in histopathology (joint stenosis, cartilage destruction, synovial hyperplasia and inflammatory cell infiltration) in rats

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Asian Pac J Allergy Immunol

Caracci MO, Avila ME, Espinoza-Cavieres FA, Lopez HR, Ugarte GD, De Ferrari GV

In addition to limited absorption via the IF, the intake of high-dose supplements leads to passive diffusion, i.e., the vitamin can freely enter the bloodstream without IF binding and receptor uptake