Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (Vinciguerra et al., 2020), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (Vinciguerra et al., 2020
10.1007/BF00251008 127 GiuglianoD.VarricchioM.CercielloT.VaranoR.SaccomannoF.GiannettiG
On top of this, glutathione production drops significantly as we age, leading to an inevitable imbalance of too much toxic stress and inflammation and not enough antioxidants to counter it
In this context, improving dietary intake of GSH could represent a relatively attractive, simple, low cost, and safe [81] strategy against cancer
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