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The extreme appetite suppression could trigger restrictive patterns in susceptible individuals

They improve as the body adapts to each dose level

Dairy products and fatty foods slow gastric emptying even further, amplifying the delayed-digestion effect of the medication itself

This matters for fat loss because chronic inflammation is now understood to be a driver of insulin resistance, which in turn makes losing body fat significantly harder

Retinal experts do recommend obtaining a baseline eye exam and considering closer follow-up of patients on GLP-1RAs within the first 12 to 18 months of starting the drug, particularly for those who have more severe DR at baseline, high baseline HbA 1c percentage, and rapid improvement in glycemic control similar to the characteristics of the patients enrolled in SUSTAIN 6