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These arent just side effects

In cultured astrocytes, the truncated isoform of the TrkB receptor (TrkB-T1, also known as TrkB-Tc) mediates rapid intracellular Ca 2+ transients in response to brief BDNF exposure

However, it isnt necessarily something that everyone needs, at least in the same capacity

In AD, altered A 2A and A 1 receptor-mediated signaling modulates EAAT2 expression, AQP4 polarization, and inflammatory states, while P2X 7 receptor hyperactivation exacerbates neuroinflammation and astrocyte-mediated cell death

I mean, we look at across various metrics, you know, in leverage and coverage metrics, we see overall trends are actually improving