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In Vitro / Preclinical Disclaimer: The research findings described above were observed in laboratory (in vitro) and/or animal model studies

As a widely used model of obesity and type 2 diabetes, KKAy mice develop obesity and insulin resistance accompanied by hepatic steatosis at an early age 58

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In the db/db mouse model (a genetic model of obesity and T2D), GPER expression is significantly decreased, closely correlating with the worsening of insulin resistance [20]

People often fail to connect the two events because of this lag