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So the biological rationale is real and multi-pronged

10.1016/j.ejphar.2012.01.010 Summary Keywords acetaminophen, phytic acid, iron, SIRT -1, CYP2E1 , liver Citation Hassan HM, Abdel-Halim NHM, El-Shenbaby I, Helmy MA, Hammad MO, Habotta OA, El Nashar EM, Alghamdi MA, Aldahhan RA, Al-Khater KM, Almohaywi B and Farrag EAE (2024) Phytic acid attenuates acetaminophen-induced hepatotoxicity via modulating iron-mediated oxidative stress and SIRT-1 expression in mice

Additionally, in the context of lowered ATP production, which is a hallmark of mitochondrial diseases, it is important to note that NAC, essentially only being a form of cysteine, will require 2 ATP molecules to be converted to glutathione

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