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Furthermore, it should be administered with caution in patients with renal impairment, as it may heighten the risk of adverse reactions

In contrast, in AMYRs bound to rAmy 15 or the pramlintide analogue, San385 16 , an Asn at the equivalent peptide position (N14 rAmy ) adopts an upward rotamer that is exposed to the solvent environment and forms a H-bond with the backbone of L291 ECL2 (Fig

The table below shows where each has evidence and which side holds the stronger tier in this pair

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