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Patients with a history of cobalt allergy may be at increased risk, as all cobalamins (including hydroxocobalamin and cyanocobalamin) contain a cobalt atom in their molecular structure

Neurotherapeutics 13, 833843

Some background information first

Increased brain vitamin D receptor expression and decreased expression of cathelicidin antimicrobial peptide in individuals who died by suicide

At $795 per cycle, the stack addresses both local tissue repair and systemic inflammation simultaneously, and the clinical rationale is straightforward: the two peptides work through non-overlapping mechanisms that produce additive effects when both are present