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DFX is also orally available and highly protein-bound (Gottwald et al., 2020), which potentially limits the efficacy of BBB penetration

Agitation (e.g., shaking, stirring, and shearing) of protein solutions can promote aggregation at the airliquid interfaces, where protein molecules may align and unfold, exposing their hydrophobic regions for charge-based association (2)

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C-phycocyanin and quaternized chitosan based antibiotic-free hydrogels with antioxidant and antibacterial activity for wound healing