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The doses were representative of the average MTX IC50 (96 hours) across all cell lines (18.4 nM)

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Although renal events were not investigated in the primary ELIXA trial, an exploratory analysis of renal outcomes was performed [43]

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We have to figure out how to close the gap between the amount that healthcare organizations pay to provide care versus what we get reimbursed for providing the care because we pass a lot of that cost onto the patient