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Moreover, because glutamine is the major fuel source for the cells of the small intestine, clinical studies have shown it to heal leaky gut

EMBO J 14(23):58245832

In the UUO model, gasdermin-induced NET formation promoted MMT in macrophages by inducing nuclear traslocation of p65 [109] and the production and release of T-cell chemokines CXCL9/10/11 thus facilitating the infiltration of cytotoxic CD8 + T cells, which produce granzyme B to mediate kidney fibrosis [110]

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There is evidence that metformin can increase the abundance of microbiota which can all produce SCFAs such as Butyrivibrio , Bifidobacterium , Megasphaera , Prevotella , and so on (de la Cuesta-Zuluaga et al., 2017)