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human data still developing
Unlike deficiency states, which produce well-characterised neurological and haematological symptoms, there is no clearly defined clinical syndrome associated with B12 excess from supplementation alone
Unlike genomic or proteomic approaches that capture upstream pathology, metabolomics reveals real-time functional alterations, which may precede structural brain changes, particularly relevant in conditions such as AD
Neurodegenerative diseases: oxidative stress meets neuroinflammation Role of oxidative stress and neuroinflammation in neurodegenerative diseases Neurodegenerative diseases share common features such as oxidative damage, neuroinflammation, autophagy dysfunction, protein aggregation, and mitochondrial defects [2, 55]
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