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It can be caused by a B12 deficiency ( Many adults and kids who have B12 deficiency report experiencing paresthesia, a burning or pins-and-needles sensation in certain areas of the body like the hands and feet

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Its actin-binding active site is the heptapeptide LKKTETQ at residues 17 to 23

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Investigational interest includes relationships to oxidative metabolism , sirtuin-linked pathways, and age-related bioenergetic decline