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A pivotal study published in the New England Journal of Medicine reported that participants who received the highest dose of Zepbound (15 mg) lost an average of 22.5% of their body weight after 72 weeks of treatment

Eli Lilly, maker of tirzepatide-based drugs Mounjaro and Zepbound, has also begun facing similar claims related to the broader GLP-1 drug class

Orforglipron (Foundayo) launched April 1, 2026 at $149-$299 a month with no food or water restrictions and slightly better tolerability data on long-term use

[DOI] [PubMed] [Google Scholar] 248.Singh S, Rathore BS, Verma P, Kumar S

Dehydration can exacerbate constipation and reduce the efficacy of many laxative agents