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As a consequence, the main mitochondrial proteome (~1500 proteins) is encoded by the nucleus, translated in the cytosol and imported into the mitochondria through specific translocator complexes (TIM and TOM) of the inner mitochondrial membrane (IMM) and outer mitochondrial membrane (OMM), respectively

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Fission can fragment mitochondria, making them more vulnerable to damage and dysfunction, while promoting the release of pro-apoptotic factors that increase cell death likelihood (50)

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