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Although probably best recognized for its importance in arousal regulation and allergic inflammatory reactions, histamine plays a role in a diverse range of biological functions

The neuroinflammatory response assumes a critical role in mediating depression, as evidenced by elevated levels of pro-inflammatory cytokines within the central nervous system and aberrant activation of astrocytes and microglia ( Microglia are specialized cells of the central nervous system that exhibit macrophage-like properties, playing a crucial role in neuroinflammation

Serious allergic reactions are rare