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the presence of at least one G allele causing an anticipated disease onset of 5.4 years 65

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In the TRIUMPH-1 trial, Retatrutide's highest dose resulted in an average weight loss of 28.3% at 80 weeks, compared to tirzepatide's 20.9% in the SURMOUNT-1 trial

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Intraperitoneal glucose tolerance tests (IPGTTs) C57BL/6 WT mice were fed a standard chow diet or a rodent diet with 10 kcal% fat and 2% cholesterol (D01101902CR, Research Diets, Inc) for 5 weeks (8-9 female mice per condition)