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The Journal ofclinical investigation, 127(12), 42174227

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Here's what to expect: Typical Semaglutide Titration: Weeks 1-4: 0.25 mg weekly (lowest dose) Weeks 5-8: 0.5 mg weekly Weeks 9-12: 1.0 mg weekly Weeks 13-16: 1.7 mg weekly Week 17+: 2.4 mg weekly (maintenance) Typical Tirzepatide Titration: Weeks 1-4: 2.5 mg weekly Weeks 5-8: 5 mg weekly Weeks 9-12: 7.5 mg weekly Weeks 13-16: 10 mg weekly Weeks 17-20: 12.5 mg weekly Week 21+: 15 mg weekly (maintenance) You'll have a nurse check-in at each dose adjustment to monitor tolerability, appetite suppression, weight change, and side effects

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By then the lesion can be of quite a considerable size and since they occur in heavily sun-exposed sites, definitive treatment can be a toss-up between curative therapy with severe cosmetic defects or a less aggressive approach taking into account the likelihood of invasive disease occurring and the patients co-morbidities and age