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This metabolic hierarchy is analogous to human cells such as intestinal epithelial cells (IECs), in which increased amounts of autophagy occurs when access to microbially derived nutrients is scarce, as shown in germ-free mouse experiments [30]

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Newer research paints a different picture: Several trials and reviews report higher 25-hydroxyvitamin D levels in patients on statins, possibly through improved absorption or reduced catabolism via CYP3A4

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Purity, dosing, long-term outcomes, and safety are not well established in human trials