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Your doctor will regularly check your kidney function, including eGFR and creatinine, because reduced kidney function increases the risk of lactic acidosis with metformin

Procedures used to generate Bmal1 lox/lox / Pax8-rtTA /LC-1 Cre mouse strain (bred on the genetic background of the C57BL/6J mouse from The Jackson Laboratory) were described previously (12)

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This maximum should never be exceeded, as doses above this threshold significantly increase the risk of serious liver damage, even in people with healthy livers

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