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The inhibition of oxidative stress, inflammation, fibrosis, and induction of natriuresis have been mainly implicated as mechanisms underlying the attenuation of DKD by GLP-1RAs ( Figure 1 )
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Because TXNIP expression decreases under conditions of reduced ROS 44 , we hypothesized that metformin lowers intracellular ROS by enhancing antioxidant defenses and NADPH availability
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