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Primary fragment screening by LO-NMR Whilst the XChem screen highlighted the possibility of obtaining hit matter in the TIN2 TBM leucine pocket of TRF1 TRFH , it also raised questions about the tractability of the fragment hits obtained using the available crystal system, especially given the crystal contacts and poor hit confirmation rate by the orthogonal CPMG assay

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Without enough glutathione to neutralize the NAPQI, this toxic substance begins to build up

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NAPDH Oxidase converts oxygen to Super Oxide (O 2 ) mainly in neutrophils Myeloperoxidase (MPO) converts peroxide (H2O2) into Hydrochloric Acid (HOCl) mainly in neutrophils Fenton Reaction generates Hydroxide (OH-) from peroxide (H2O2) using iron Superoxide Dismutase (SOD) converts Super Oxide (O 2 ) to peroxide (H2O2) Glutathione convert Hydroxide (OH-) to water Catalase converts Peroxide (H2O2) to water We will see in the immunology section that that a defect in NADPH Oxidase causes Chronic Granulomatous disease