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While GHK-Cu is not a growth hormone secretagogue, it exerts potent localised effects relevant to both hair and skin: Promotion of angiogenesis , increasing capillary density around follicles Stimulation of stem cell migration and differentiation Inhibition of transforming growth factor beta (TGF-) , a cytokine associated with follicular miniaturisation Enhancement of collagen and elastin synthesis , improving scalp elasticity and barrier function Topical GHK-Cu formulations, available through Dn Research in research-grade purity, can be incorporated into routine scalp applications to directly support the hair follicle microenvironment

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Berberine is often compared to metformin because it improves insulin sensitivity and regulates blood sugar levels