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Food Chem 106(3):11131119

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doi: 10.1007/s11883-022-01062-2 144 LiuCZouYQianHLiuCZouYQianH

Headache disorders may be a risk factor for the development of new onset hypothyroidism

While GHK-Cu is generally well-tolerated in topical research, certain contraindications or precautions should be considered, especially for systemic research or in specific populations: Systemic Research: For systemic applications, GHK-Cu is generally not recommended for subjects who are pregnant, breastfeeding, have active cancer, or suffer from Wilsons disease (a condition involving copper accumulation)